Endoscopies are generally safe when performed by physicians with specialized training and experience. In rare circumstances, a perforation of the digestive tract may occur, which could possibly require surgery to repair. Minor bleeding may occur at the site of a polypectomy, but this typically stops on its own or may be controlled by the endoscopist. There could be adverse reaction to the sedatives given for the procedure, but this too is rare.
Severe abdominal pain, fever or rectal bleeding should be reported to the endoscopist during the post-procedure recovery period, or if they are experienced within a couple days following an endoscopic procedure.